Gadolinium-Based MRI Contrast Agents Induce Mitochondrial Toxicity and Cell Death in Human Neurons, and Toxicity Increases With Reduced Kinetic Stability of the Agent (2019).

Article link: https://journals.lww.com/investigativeradiology/fulltext/2019/08000/gadolinium_based_mri_contrast_agents_induce.1.aspx

Authors and Affiliations: Bower, Danielle V. MD, PhD*,†; Richter, Johannes K. MD*; von Tengg-Kobligk, Hendrik MD*,†; Heverhagen, Johannes T. MD, PhD*,†; Runge, Val M. MD*,†

From the *Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, University Hospital of Bern; and

†Department for BioMedical Research, University of Bern, Bern, Switzerland.

Received for publication January 8, 2019; and accepted for publication, after revision, March 1, 2019.

Johannes T. Heverhagen and Val M. Runge share the senior authorship.

Author contributions: D.V.B. and V.M.R. conceived of the overall project. D.V.B. conceived the experimental plans, designed the protocols, conducted the experiments, analyzed the data, and produced the final figures. J.K.R. validated reproducibility of quantifications as a second reader. D.V.B. wrote and revised the manuscript. H.v.T.K. and J.T.H. financed and oversaw the project. All authors discussed the results and approved the final manuscript.

This work was performed in the laboratory for Experimental Radiology, Inselspital, University Hospital of Bern, located in the Department for BioMedical Research (DBMR), University of Bern. Imaging was conducted at the Live Cell Imaging Core Facility of the Microscopy Imaging Center at the University of Bern. The experiments measuring oxygen consumption and acidification were performed in the laboratory of Stefan Freigang in the Institute of Pathology at the University of Bern.

This study was funded by the Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, University Hospital of Bern, University of Bern, Bern, Switzerland.