Metalloglycobiology: The power of metals in regulating glycosylation (June 2023).

Cellular/Mitochondria dysfunctionGeneral Chemistry

Jun 20

Written By Bridget Belo

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Article link: https://www.sciencedirect.com/science/article/pii/S0304416523001101?via%3Dihub

Authors and Affiliations: Zoé Durin, Marine Houdou, Dominique Legrand, François Foulquier

Univ. Lille, CNRS, UMR 8576 – UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F- 59000 Lille, France

ABSTRACT: The remarkable structural diversity of glycans that is exposed at the cell surface and generated along the secretory pathway is tightly regulated by several factors. The recent identification of human glycosylation diseases related to metal transporter defects opened a completely new field of investigation, referred to herein as “metalloglycobiology”, on how metal changes can affect the glycosylation and hence the glycan structures that are produced. Although this field is in its infancy, this review aims to go through the different glycosylation steps/pathways that are metal dependent and that could be impacted by metal homeostasis dysregulations.

Metalloglycobiologymetalloproteinsenzyme cofactors, structural stabilization of biomolecules, role as secondary messengers, vesicular traffickingenzyme cofactorsstructural stabilization of biomoleculessecondary messengersvesicular traffickingsecretory pathwaysendoplasmic reticulummetal homeostasis

Bridget Belo

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